1. Used as an intermediate formedicines, pesticides, dyes and other organic compounds. It is an important rawmaterial for the manufacture of sulfonamides and folic acid. It can also beused as an antistatic agent for synthetic fibers. It is an important rawmaterial for sulfadiazine, sulfamerazine, sulfamethazine and folic acid. 

2. As a strong denaturant in theextraction of total RNA from cells. The guanidine hydrochloride solutioncan dissolve the protein, cause destruction of the cell structure, destructionof the nucleoprotein structure, and dissociate from the nucleic acid. Inaddition, the RNase can be inactivated by a reducing agent such as guanidinehydrochloride.